Title of article :
Evaluation the effects of Cissus modeccoides hot aqueous extract on alloxan-induced diabetic rats
Author/Authors :
Pradit, Waranee Science and Technology Research Institute - Department of Biology - Faculty of Science - Chiang Mai University, Thailand , Khumpook, Taddaow Department of Biology - Faculty of Science - Chiang Mai University, Thailand , Saenphet, Kanokporn Department of Biology - Faculty of Science - Chiang Mai University, Thailand , Saenphet, Supap Department of Biology - Faculty of Science - Chiang Mai University, Thailand , Chomdej, Siriwadee Department of Biology - Faculty of Science - Chiang Mai University, Thailand
Abstract :
Introduction: In this study, the hypoglycemic effects and the safety of Cissus modeccoides (CM) were assessed on alloxan-induced diabetic rats. Methods: Various concentrations of CM hot aqueous extract were orally administered to alloxan-induced diabetic rats for 30 days. Blood glucose level, hematological and biochemical parameters, and gene expression level were evaluated. Results: After CM treatment, diabetic rats presented nonreduced blood glucose level and unimproved body weight. Increased blood urea nitrogen was observed in CM-treated groups as well. Although hematological parameters and cholesterol level revealed nonsignificant effects from CM, decreased expression levels of the insulin receptor in the pancreas and insulin receptor substrate 2 and glucose transporter 2 in the liver were demonstrated in CM-treated groups. Nephrin in the kidney of CM groups was highly expressed. Conclusion: The results of this study revealed adverse effects and toxicity of CM extracts in diabetic rats.
Keywords :
Alloxan , blood glucose , Cissus modeccoides , gene expression , toxicity
Journal title :
Journal of Reports in Pharmaceutical Sciences
