Evaluation of the Validity of a Nonlinear JShaped DoseResponse Relationship in Cancers Induced by Exposure to Radiofrequency Electromagnetic Fields

The radiofrequency electromagnetic fields (RFEMFs) produced by widely used mobile phones are classified as possibly carcinogenic to humans by International Agency for Research on Cancer (IARC). Current data on the relationship between exposure to RFEMFs generated by commercial mobile phones and brain cancer are controversial. Our studies show that this controversy may be caused by several parameters. However, it seems that the magnitude of exposure to RFEMFs plays a basic role in RFinduced carcinogenesis. There is some evidence indicating that, in a similar pattern with ionizing radiation, the carcinogenesis of nonionizing RFEMF may have a nonlinear doseresponse relationship. In this paper, the evidence which supports a nonlinear Jshaped doseresponse relationship is discussed.