Title of article :
A Quick update from the Past to Current Status of Human Pluripotent Stem Cell-derived Hepatocyte culture systems
Author/Authors :
Zahmatkesh ، Ensieh Department of Stem Cells and Developmental Biology - Royan Institute for Stem Cell Biology and Technology, Cell Science Research Center - Academic Center for Education, Culture and Research (ACECR) , Vosough ، Massoud Department of Stem Cells and Developmental Biology - Royan Institute for Stem Cell Biology and Technology, Cell Science Research Center - Academic Center for Education, Culture and Research (ACECR)
Abstract :
Pluripotent stem cells (PSCs) may be offered as an unlimited cell source for the hepatocyte generation. The generation of hepatocytes from stem cells in vitro would provide an alternative cell source for applications in drug discovery and cell transplantation. In this review, we discuss different approaches to generate pluripotent stem cell-derived hepatocytes, advantages, limitations for each method and finally, how three-dimensional (3D) strategy can improve the maturation of PSCs -derived hepatocytes.
Keywords :
Pluripotent stem cell , Hepatocyte differentiation , Tissue engineering , Organoids , Drug , screening
Journal title :
Medical Laboratory Journal
Journal title :
Medical Laboratory Journal
