Title of article :
Influence of arabinofuranosylcytosine-5`-monophosphate and its emoxipin salt on viability and functional status of peripheral blood lymphocytes subpopulations
Author/Authors :
Sysa ، Aliaksei International Sakharov Environmental Institute (ISEI) - Belarusian State University , Labai ، Maryna International Sakharov Environmental Institute (ISEI) - Belarusian State University , Kvasyuk ، Eugeni International Sakharov Environmental Institute (ISEI) - Belarusian State University , Ivuts ، Uliana International Sakharov Environmental Institute (ISEI) - Belarusian State University , Khanchevskii ، Maksim International Sakharov Environmental Institute (ISEI) - Belarusian State University
Abstract :
The influence of the modified nucleotide arabinofuranosylcytosine-5`-monophosphate in the form of the free acid (Ara-CMP) and its salts with emoxipin (Ara-CMP+Em) on the viability of peripheral blood mononuclear cells, the lymphocyte proliferation of mitogen-stimulated cells was studied. It was shown that emoxipin - the compound with strong antioxidant properties - does not lead to inhibition of the main function of the antimetabolite Ara-CMP, namely, cell growth arrest (p = 0.96) and lysis of target cells (p = 0.97). Under the conditions of nonspecific stimulation of lymphocytes, Ara-CMP at high concentrations (10^-4 M) increased in both IFNγ-secreting T-lymphocytes (five times) and IFNγ-secreting other lymphocytes (three times). Emoxipin led to almost complete leveling of the detected effect.
Keywords :
Antimetabolites , Ara , CMP , Antioxidants , Emoxipin , Proliferation
Journal title :
Progress in Chemical and Biochemical Research
Journal title :
Progress in Chemical and Biochemical Research
