Title of article :
A new pyrrolidinyl-piperazine alkaloid derivative from Oxyanthus speciosus DC.(Rubiaceae)
Author/Authors :
Nyobe ، Judith Caroline Ngo Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry - Faculty of Science - University of Douala , BIKÉLÉ ، DÉSIRÉ MAMA Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry - Faculty of Science - University of Douala , Fodouop ، Matiedjie Becky Department of Pharmaceutical Sciences - Faculty of Medicine and Pharmaceutical Sciences - University of Douala , Mpondo ، Emmanuel Mpondo Department of Pharmaceutical Sciences - Faculty of Medicine and Pharmaceutical Sciences - University of Douala , Ndom ، Jean Claude Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry - Faculty of Science - University of Douala
Abstract :
A new pyrrolidinyl-piperazine alkaloid derivative named 2-(7’-methylhexyloxy)furan-5’-yl)-6- (pyrrolidin-7-yl)piperazine (1), along with five known compounds were isolated from methanolic extract of the roots of Oxyanthus speciosus DC. (Rubiaceae). The structure of this new alkaloid was elucidated on the basis of the relevant NMR and MS analyses. Compound (1) possesses potent in vitro anti-inflammatory activity by protein denaturation assay with an IC50 value of 1.930 ± 0.9123 μg/mL. The obtained results indicated that the crude methanolic extract of O. speciosus DC. roots and its isolated pyrrolidinyl-piperazine alkaloid have potentials for further development as an effective and natural anti-inflammatory agents.
Keywords :
Anti , inflammatory activity , Oxyanthus speciosus DC , Rubiaceae
Journal title :
Trends In Phytochemical Research
Journal title :
Trends In Phytochemical Research
