Title of article
Elucidating the Anti-aging Ursolic Acid through Evaluation of SIRT1 and SIRT6 in the Mice Skeletal Muscle Tissue
Author/Authors
Ahmadzadeh, S Department of Biochemistry - Faculty of Basic Sciences - Sanandaj Branch - Islamic Azad University, Sanandaj , Noori, A.R Department of Biochemistry - Faculty of Biological Science - Tarbiat Modares University, Tehran , Bakhtiari, N Department of Biology - Faculty of Biological Sciences - Islamic Azad University - North-Tehran Branch, Tehran , Hemmati, R Department of Biology - Faculty of Basic Science - Shahrekord University, Shahrekord - Biotechnology Research Institute - Sharekord Univrsity
Pages
11
From page
47
To page
57
Abstract
The process of skeletal muscle aging is linked to the development of age-related diseases such as metabolic syndrome, diabetes, cancer
and Alzheimer’s disease. Hence, to further investigate the effect of Ursolic Acid (UA) endorses previous studies on skeletal muscle
rejuvenation, we tested whether UA alters two prominent anti-aging biomarkers such as SIRT1 and SIRT6 in skeletal muscle. UA is a
triterpenoid compound widely found in natural plants and fruits, with known effects on skeletal muscle. To conduct this experiment, UA
dissolved in Corn Oil (200 mg ml-1) was administrated (200 mg kg-1 IP injection) twice daily for 7 days to male aged-mice C57BL/6. Then,
mice skeletal muscle tissues were isolated and proteins were examined through immunofluorescence microscopy. Our findings clearly
illustrated that UA enhances SIRT1 (~3.5 folds) and SIRT6 (~4 folds) expression levels, p < 0.001. To the best of our knowledge, UA
seems to imitate the effects of exercise by increasing the SIRT1 and SIRT6 proteins level in the skeletal muscle tissue. Finally, UA can be
recommended as a superior candidate to improve the diseases associated with skeletal muscle aging.
Keywords
Ursolic acid , Skeletal muscle , SIRT1 , SIRT6
Journal title
Biomacromolecular Journal
Serial Year
2019
Record number
2512128
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