Extraction of Cetirizine Using Magnetic Nanoparticles of Hengam Island Sand and Determination by HPLC

In present work Hengam island sands were used for preparation of new magnetic nanoadsorbent. These sands have intrinsic magnetic properties due to possess specific compounds such as Fe3O4. It was modified by surface activator agent namely 3(Glycidyloxypropyl)trimethoxysilane to produce effective nanoadsorbent. After preparation of this nanoadsorbent, Its physical and chemical properties was verified using several techniques such as FTIR, TGA/DTG, XRD and SEM. Nanoadsorbent was used as a solid phase to extraction of cetirizine from aqueous solutions and then its determination was done by HPLC. Effective analytical parameters such as pH of sample solution (pH=4), dosage of nanoadsorbent (100 mg), zero charge (pHz=5), breakthrough volume (500 mL) and contact time (15 min) were evaluated and optimized. Furthermore, figures of merit parameters such as precision (RSD=1.44%), limit of detection (LOD=1.1 µg L1) and linear dynamic range (LDR=0.01250 mg L1) were obtained. Also for validation the accuracy of method, amount of cetirizine in two real samples were successfully determined.