Title of article :
Connection of poly (Propylene imine) dendrimer to curcumin and investigation into anti-cancer effects of its products
Author/Authors :
Mohammadpour ، Keyhan Department of Chemistry - Faculty of Science - Islamic Azad University, Khorramabad Branch , Salahvarzi ، Sabah Department of Chemistry - Faculty of Science - Islamic Azad University, Khorramabad Branch , Dadgar ، Zeynab Department of biology - Faculty of Science - Arak University
Abstract :
The dendrimers are the macromolecules that branch out from the same nuclear and they finally reach the same central nucleus. The solubility of the dendrimer is strongly affected by the surface groups. These compounds are the ideal carriers for biomedical applications. One of the oldest identified dendrimer is poly (propylene imine) dendrimer (denoted as PPI dendrimer). The present study consists of two sections. In the first section, the interaction between the (PPI) dendrimer with different molar ratios of curcumin was investigated at the presence or absence of the ultrasonic waves. In the second section, the anti-cancer effects of this compound on BRC-9 cell line (of breast cancer cells) were investigated with the help of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay.
Keywords :
Poly (propylene imine) dendrimer , Curcumin , BRC , 9 , Cancer cell
Journal title :
Asian Journal of Nanoscience and Materials
Journal title :
Asian Journal of Nanoscience and Materials
