Title of article :
Experimental and Clinical Evaluation of Plantago australis Extract as an Anti-Inflammatory Agent to Treat Oral Pathologies
Author/Authors :
Flores ، Isadora Luana Department of Dentistry - Federal University of Juiz de Fora, Campus Avançado Governador Valadares , Gamba ، Thiago de Oliveira Post-Graduate Program in Oral Radiology - Piracicaba Dental School - University of Campinas , de Carvalho ، Rodrigo Varella School of Dentistry - Meridional Faculty (IMED) , Lund ، Rafael Guerra Post-Graduate Program in Dentistry - Pelotas Dental School - Federal University of Pelotas , Etges ، Adriana Department of Semiology and Clinics, Post-Graduate Program in Dentistry - Dental School - Federal University of Pelotas
Abstract :
Background: Plantago australis is a native plant from Southern Brazil used to reduce inflammation. Interestingly, there are no previous studies evaluating its use to treat oral lesions. Objectives: The study aimed to investigate in vivo the anti-inflammatory activity of 10% ethanol extract of P. australis in recurrent aphthous stomatitis (RAS), erosive lichen planus (ELP) and actinic cheilitis (AC). Methods: Thirty patients with RAS, ELP and AC were treated topically with 10% P. australis solution-based or cream. Results: In the comparison of in vivo data before and after the treatment and between different lesions, all P values were less than 0.05. Conclusions: The pharmaceutical formulation of 10% P. australis was therapeutically effective in the subjects with inflammatory oral lesions of RAS, ELP and AC.
Keywords :
Plantago spp. , Anti , Inflammatory Agents , Oral Pathology , Clinical Study
Journal title :
Jentashapir Journal of Health Research
Journal title :
Jentashapir Journal of Health Research
