Stem Cell Conditioned Medium as a Novel Treatment for Neuroinflamation Diseases

Inflammation is a most important factor that mentioned as causes of many neurodegeneration disease like Parkinson, Alzheimer and ALS. Neuroinflammation is poorly understood like neuroinflamation in Alzheimer and Parkinson. Studies showed that even chronic peripheral inflammation that observe in many diseases like arthritis can cause neurodegeneration and dementia in some cases. The neuroinflammation in many dementia diseases are local and information is limited about it. One of the most important treatments for dementia diseases like Alzheimer is the use of anti-inflammatory drugs like NSAIDS but unfortunately they have poor therapeutic effects on neuroinflammation. Recent studies investigated that conditioned medium extracted from mesenchymal stem cells have neuromodulator effects even could prevent neurodegeneration in some cases. In this study we review effects of mesenchymal stem cell conditioned medium in different central nervous system (CNS) disease associated with neuroinflammation.