Association of Adipokine Resistin With Homeostasis Model Assessment of Insulin Resistance in Type II Diabetes

Background: Resistin is a recently discovered signal molecule that has been linked to obesity, type II diabetes mellitus (T2DM) and metabolic syndrome. Objectives: This study aimed to assess whether serum resistin is associated with insulin resistance and glucose concentration in males with T2DM. Patients and Methods: Thirty two adult non-trained males with type II diabetes, 34-48 years old and 88-110 kg of body weight, participated in this study by accessible sampling. Fasting blood samples were collected from all participants in order to measure serum resistin, insulin and glucose concentration. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was calculated using fasting insulin and glucose. Relations between variables were determined by Pearson correlations. Results: We found that serum resistin had a positive significant correlation with insulin resistance (P = 0.000, r = 0.64). No significant correlation was found between serum resistin and fasting glucose concentration in the studied patients (P = 0.21, r = 0.23). Conclusions: Based on these data, we can argue that circulating glucose concentration is not directly affected by serum resistin in T2DM. It seems that resistin affects glucose indirectly, through insulin resistance.