Title of article :
Modulation of lung inflammation and immune markers in asthmatic rats treated by Portulaca oleracea
Author/Authors :
Kaveh, Mahsa Department of Biology - Science and Research Branch - Islamic Azad University , Eidi, Akram Department of Biology - Science and Research Branch - Islamic Azad University , Neamati, Ali Department of Biochemistry and Biophysics - Mashhad Branch - Islamic Azad University , Boskabady, Mohammad Hossein Neurogenic Inflammation Research Center - Mashhad University of Medical Sciences
Abstract :
Objective: Previous studies indicated anti-inflammatory effects for Portulaca oleracea in various inflammatory disorders. In this study, the effects of P. oleracea on bronchoalveolar lavage fluid (BALF) levels of total protein (TP), Phospholipase A2(PLA2) and IgE in sensitized rats were examined.
Materials and Methods: Male rats were randomly divided into six groups namely, control (group C), sensitized rats (group S), sensitized animal treated with three concentrations of the extract of P. oleracea and dexamethasone (n = 8 for each group). The levels of TP, PLA2 and IgE in BALF were measured.
Results:The levels of TP, PLA2and IgE were significantly increased in the BALF of group S compared to group C (pand IgE compared to group S (pand IgE (p
Conclusion: The results indicated anti-inflammatory and immunomodulatory effects of P. oleracea in sensitized rats (as an animal model of asthma) which was equal or more marked than dexamethasone at studied concentrations.
Keywords
Keywords :
Portulaca oleracea , Total protein Phospholipase A2 (PLA2) , Immunoglobulin E , Rat model of asthma
Journal title :
Avicenna Journal of Phytomedicine AJP)
