The Importance of Group 2 Innate Lymphoid Cells to Improve the Protective Immunity in Parasitic Helminth Infections

Helminthiasis is a neglected public health challenge worldwide. The relevance of the important role of group 2 innate lymphoid cells (ILC2s) in the protection induced by type 2 immune responses against helminth infections has recently regained attention. The parasitic helminth infections remain as a major public health concern worldwide, particularly in tropical countries in several areas of Africa, Asia, and South America. It has been demonstrated in the experimental mouse models that ILC2s induce significant secretion of type 2 cytokines and develop protective immunity against parasitic helminths infections. However, the effects of helminth-induced immunity mediated by ILC2s have not yet been clearly defined. This review discusses the current status of the researches related to the evidence of ILC2s to improve the protective immunity in parasitic helminth infections and how these cells promote parasitic helminth expulsion.