Title of article :
Osmolarity: A hidden factor in Nanotoxicology
Author/Authors :
Moayyedi, Saeid Department of Medical Nanotechnology - School of Advanced Technologies in Medicine (SATiM) - Tehran University of Medical Sciences , Mashinchian, Omid Institute of Bioengineering - School of Life Sciences - Ecole Polytechnique Fédérale de Lausanne (EPFL) - Lausanne, Switzerland , Dinarvand, Rassoul Nanotechnology Research Centre - Faculty of Pharmacy - Tehran University of Medical Sciences
Abstract :
In the field of drug delivery, long circulating nanocarriers in the blood have many advantages such as targeted drug delivery and sustained release. Based on our current knowledge, evaluation of the effect of
long circulating nanocarriers in the blood stream on osmolarity of plasma has not been reported before. In
this study, osmotic pressure developed by some commercially available nanocarriers was estimated based on
Van't Hoff equation. It is noteworthy that theoretically, nanocarriers do not have any significant effect on
osmolarity of plasma. However, it is worth being evaluated experimentally in order to be taken into account in future studies.
Keywords :
Nanocarriers , Drug delivery , Osmotic pressure
Journal title :
Daru:Journal of Pharmaceutical Sciences
