Author/Authors :
Hosseinpour Mina Department of Mechatronics - School of Engineering Emerging Technologies - University of Tabriz - Tabriz, Iran , Azimirad Vahid Department of Mechatronics - School of Engineering Emerging Technologies - University of Tabriz - Tabriz, Iran , Alimohammadi Maryam Department of Mechatronics - School of Engineering Emerging Technologies - University of Tabriz - Tabriz, Iran , Shahabi Parviz Neuroscience Research Center - Tabriz University of Medical Sciences - Tabriz, Iran , Sadighi Mina Neuroscience Research Center - Tabriz University of Medical Sciences - Tabriz, Iran , Ghamkhari Nejad Ghazaleh Neuroscience Research Center - Tabriz University of Medical Sciences - Tabriz, Iran
Abstract :
Carbon nanotubes (CNTs) are
novel candidates in nanotechnology with a
variety of increasing applications in medicine
and biology. Therefore the investigation of
nanomaterials’ biocompatibility can be an
important topic. The aim of present study
was to investigate the CNTs impact on cardiac
heart rate among rats.
Methods: Electrocardiogram (ECG) signals
were recorded before and after injection of
CNTs on a group with six rats. The heart rate
variability (HRV) analysis was used for signals analysis. The rhythm-to-rhythm (RR) intervals
in HRV method were computed and features of signals in time and frequency domains were
extracted before and after injection.
Results: Results of the HRV analysis showed that CNTs increased the heart rate but generally
these nanomaterials did not cause serious problem in autonomic nervous system (ANS) normal
activities.
Conclusion: Injection of CNTs in rats resulted in increase of heart rate. The reason of phenomenon
is that multiwall CNTs may block potassium channels. The suppressed and inhibited IK and
potassium channels lead to increase of heart rate.
