Author/Authors :
Jahanara, Abbas Department of Pediatrics - Tropical Disease Research Center - Kerman University of Medical Scineces , Kerman, Iran , Hosseininasab, Ali Department of Pediatrics - Tropical Disease Research Center - Kerman University of Medical Scineces , Kerman, Iran , Arabzadeh, Ali Mohammad Department of Virology - Clinical Research Database - Kerman University of Medical Scineces, Kerman, Iran , Iranmanesh, Zahra Clinical Research Database - Kerman University of Medical Scineces, Kerman, Iran , Dehghani, Azam Clinical Research Database - Kerman University of Medical Scineces, Kerman, Iran , Nikkpour, Najmeh Kerman University of Medical Scineces, Kerman, Iran
Abstract :
Introduction: Hepatitis A is caused by a virus with a similar name. As a very
contagious disease, Hepatitis A is one of the most prevalent infant infections across the
developing countries. People who have been vaccinated and also those who caught this
disease already are immune against hepatitis A. Since it was not possible and cost effective
to analyze the immunity level of all asymptomatic children, in this study, the immunity level of some children against this virus was measured in order to estimate their immunity potential against this infection.
Methods: A total of 400 6-11 years old children in Kerman County, who have referred to
the Be'sat Specialized Clinic and infants emergency care ward of Afzalipour Hospital and
their blood have been collected for any reason except diagnosing hepatitis, were studied.
Children with chronic liver, blood, immunity system deficiency and malignity were
excluded from the study. Using ELISA technique and Dia-pro Milano Italy, made by Italy
(with a sensitivity of 100% and specialty of 99.6%), their serum was analyzed in terms of
anti-hepatitis data were analyzed using SPSS 16.
Results: 42.8% of children were immune against hepatitis A. 55% and 45% of children
referred to the mentioned medical centers were girl and boy, respectively. 59.1% of boys
and 40.9% of girls were immune, but there was not any significant difference between
them. There was a direct relationship between immunity and children's age, as with
increasing their age as large as 1 year their immunity level against hepatitis A is increased
as large as 0.75%. There was not found any relationship between the immunity level and
other demographic properties.
Conclusion: Most of 6-11 children are immune against hepatitis A because of their
asymptomatic disease.
Keywords :
Children , Immunity , Antibody , Hepatitis A