Author/Authors :
Zand, Vahid Dental and Periodontal Research Center - Department of Endodontics - Dental School - Tabriz University of Medical Sciences, Tabriz , Lotfi, Mehrdad Research Center for Pharmaceutical Nano-Technology - Department of Endodontics - Dental School - Tabriz University of Medical Sciences, Tabriz , Aghbali, Amirala Department of Oral and Maxillofacial Pathology - Dental School - Tabriz University of Medical Sciences, Tabriz , Mesgariabbasi, Mehran Researcher - Drug Applied Research Center -Tabriz University of Medical Sciences, Tabriz , Janani, Maryam Department of Endodontics - Dental School - Tabriz University of Medical Sciences, Tabriz , Mokhtari, Hadi Department of Endodontics - Dental School - Tabriz University of Medical Sciences, Tabriz , Tehranchi, Pardis Department of Restorative Dentistry - Dental School - Tabriz University of Medical Sciences, Tabriz , Vahid Pakdel, Mahdi Department of Prosthodontics - Faculty of Dentistry - Tabriz University of Medical Sciences, Tabriz
Abstract :
Introduction: Bio compatibility and antimicrobial activity of endodontic materials are of utmost importance. Considering the extensive applications of mineral trioxide aggregate (MTA) in dentistry and antimicrobial properties of silver nanoparticles, this study aimed to
evaluate the subcutaneous inflammatory reaction of rat connective tissues to white MTA with
and without nanosilver (NS) particles. Methods and Materials: Polyethylene tubes (1.1×8
mm) containing experimental materials (MTA and MTA+NS and empty control tubes) were
implanted in subcutaneous tissues of seventy-five male rats. Animals were divided into five
groups (n=15) according to the time of evaluation: group 1; after 7 days, group 2; after 15
days, group 3; after 30 days, group 4; after 60 days and group 5; after 90 days. The
inflammatory reaction was graded and data was analyzed using the Kruskal-Wallis and MannWhitney U tests. Statistical significance was defined at 0.05. Results: Comparison of
cumulative inflammatory reaction at all intervals revealed that the mean grade of
inflammatory reaction to MTA, MTA+NS and control samples were 3, 2 and 2, respectively.
According to the Mann-Whitney analysis there were no significant differences between
MTA+NS and MTA (P=0.42). Conclusion: Incorporation of 1% nanosilver to MTA does not affect the inflammatory reaction of subcutaneous tissue in rat models.
Keywords :
Biocompatibility , Mineral Trioxide Aggregate , Nanosilver , Silver Nanoparticle
