Title of article
Cancer: Disease Caused by Alteration of Genes
Author/Authors
Ahmad Malik, Manzoor Department of Immunology and Molecular Medicine - Sher-I-Kashmir Institute of Medical Sciences (SKIMS) - Soura - Srinagar - Kashmir, India , Sepehri, Zahra Department of Internal Medicine - Zabol University of Medical Sciences, Zabol , Amin Shah, Zafar Department of Immunology and Molecular Medicine - Sher-I-Kashmir Institute of Medical Sciences (SKIMS) - Soura - Srinagar - Kashmir, India
Pages
3
From page
37
To page
39
Abstract
In normal cells when genetic defects occur, there are some sensitive mechanisms through
which the defect might be repaired or apoptosis might be induced. However in tumor cells such
mechanisms are not highly sensitive; therefore they cannot detect such abnormalities. This failure
in detection and/or repair of the genetic abnormality results in the survival of abnormal cells.
This survival is followed up with growth of the cells without normal control and ultimately leads
to the rise of malignant clones in the body. Pathways in which these malignant transformations
occur, are increasingly being studied to find effective treatments for different carcinomas.
Keywords
Cancer , Tumor suppressor genes , Oncogenes and low penetrance genes
Journal title
International Journal of Basic Science in Medicine (IJBSM)
Serial Year
2016
Record number
2516653
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