Title of article :
Evaluation of CD133 and CD56/NCAM expression in Wilms tumor and their association with prognostic factors
Author/Authors :
Jafarian, Amir Hossein Department of Pathology - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad , Zabolinejad, Nona Department of Pathology - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad , Mohamadian Roshan, Nema Department of Pathology - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad , Hashemi, Sara Department of Pathology - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad , Gharib, Masoumeh Department of Pathology - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad
Abstract :
Objective(s): To validate certain markers for cancer stem cell populations and their clinical importance
in Wilms tumor (WT)
Materials and Methods: Immunohistochemical study for CD133 and CD56/NCAM was performed
on forty-six cases of WT that were diagnosed between 1999 and 2015, and the association of these
markers with survival and prognostic factors was analyzed.
Results: Thirty-four (73.9%) of WTs were positive for CD133 and thirty-nine (84.8%) were positive
for CD56/NCAM. A significant positive correlation between CD133 and CD56/NCAM expression and
the National Wilms Tumor Stage (NWTS) and death was found. Moreover, overall survival time was
significantly correlated with CD133 and CD56/NCAM H-score, NWTS stage, and death.
Conclusion: It seems that CD133 and CD56/NCAM expressions can be used as strong prognostic
parameters for the survival of patients with WT and can be used to predict WT patients’ stage.
Moreover, their targeted therapies can abolish cancer stem cells in children with recurrent tumors.
Keywords :
CD133 , Immunohistochemistry , Neural cell adhesion - molecules , Stem cells , Wilms tumor
Journal title :
Iranian Journal of Basic Medical Sciences
