Author/Authors :
Savaj, Shokoufeh Department of Medicine - Firoozgar Hospital - Iran University of Medical Sciences, Tehran, Iran , Ghaffari, Mohammad Department of Medicine - Firoozgar Hospital - Iran University of Medical Sciences, Tehran, Iran , Azadi, Javad Department of Medicine - Firoozgar Hospital - Iran University of Medical Sciences, Tehran, Iran , Abbasi, Mohammad Amin Department of Medicine - Firoozgar Hospital - Iran University of Medical Sciences, Tehran, Iran
Abstract :
Acute interstitial nephritis (AIN) is known as a common cause
of acute kidney injury, found in 15% to 27% of kidney biopsies.
Drug-induced AIN is currently the most common cause of AIN.
The most common medications causing AIN are antibiotics and
nonsteroidal anti-inflammatory drugs. We describe a case of
Citrullus colocynthis (herbal remedy for diabetes mellitus and
weight reduction) that induced AIN. A 31-year-old woman with
major thalassemia, diabetes mellitus, and hepatitis C infection
was admitted because of flank pain and unexpected increase in
serum creatinine level. She had been using Citrullus colocynthis
for 3 months. Kidney biopsy results suggested AIN. She did not
respond to steroid therapy and underwent hemodialysis. We
suggest the use of Citrullus colocynthis as a herbal medicine with
extreme caution.
