COVID-19 in IgA Vasculitis

The coronavirus disease 2019 (COVID-19), classified as a pandemic by theWorldHealth Organization(WHO), has affected nearly all countries and regions around the world. Evidence to date suggests that patients with concomitant medical conditions are at higher risk for severe COVID- 19 (1). However, data regarding the comorbidities in children with COVID-19 is relatively rare (2). We report a case of suspected COVID-19 infection in a 6-year-old boy with Henoch–Schonlein purpura (HSP) complicated by diffuse alveolar hemorrhage. On April 1, 2020, the patient was brought to the emergency department of Bahrami Children’s Hospital, Tehran, Iran, because of a palpable purpuric maculopapular rash involving his left ankle and foot and signs of arthritis in the left ankle and knee. The rest of the physical examination was unremarkable. The child was admitted for further evaluation. Laboratory tests showed leukocytosis, increased ESR and CRP and mild hematuria and proteinuria. The patient was clinically diagnosed with HSP, was given supportive treatment and ibuprofen. Arthralgia and edema gradually subsided and the patient was discharged on day 3 with a prescription of ibuprofen. Two days later, the patient was readmitted with fever, tachypnea, dyspnea, O2 saturation of 94% on room air, bilateral fine rales on lung auscultation and abdominal pain associatedwithmelena. Patient’s hemoglobinwas decreased and urine analysis showed hematuria and proteinuria. Abdominal ultrasound demonstrated mural thickening of distal ileum and decreased peristalsis. Chest X-ray (CXR) showed bilateral, peripheral ground glass opacities of the lungs. COVID-19 rapid test was negative; however, a clinical diagnosis of COVID-19 was made and after PICU admission treatment started with methyl prednisolone, cloxacillin, azithromycin and hydroxychloroquine. As patient’s condition worsened and his hemoglobin level dropped to 6.1 gr/dL, packed red cells were given. COVID-19 rapid test repeat revealed negative results. The patient was suspected to have developed pulmonary hemorrhage associatedwithHSP.Bronchoscopy andbronchoalveolar lavage (BAL) showed diffuse alveolar hemorrhage. As BAL specimen tested negative for SARS-CoV-2, the patient received intravenous cyclophosphamide. However, treatment was not successful and the patient died of respiratory failure. COVID-19 is a major concern to rheumatologists as rheumatologic patients may potentially be at an increased risk of infection and death due to the underlying immune dysfunction and treatment with immunosuppressive agents (3). However, data regarding rheumatologic diseases as a risk factor for increased incidence or severity of COVID-19 in children is very scarce (4). Few reports have described adults and children presenting with maculopapular, purpuric and acro-ischemic skin lesions who were subsequently diagnosed with COVID-19 (5, 6). Moreover, vasculitis-like lesions due to endothelial damage are reported in severe forms of COVID-19 (7). At first presentation, our patient had the typical palpable purpuric skin lesions of HSP and his symptoms were successfully managed with ibuprofen. However, he was readmitted with pulmonary manifestations, which led to a clinical diagnosis of COVID-19, and exacerbation of HSP-related symptoms.