Author/Authors :
Safiri, Saeid Managerial Epidemiology Research Center - Department of Public Health - School of Nursing and Midwifery - Maragheh University of Medical Sciences, Maragheh, Iran , Qorbani, Mostafa Department of Community Medicine - School of Medicine - Alborz University of Medical Sciences, Karaj, Iran , Heshmat, Ramin Chronic Diseases Research Center - Endocrinology and Metabolism Population Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Tajbakhsh, Ramin Department of Internal Medicine - School of Medicine - Alborz University of Medical Sciences, Karaj, Iran , Eslami Shahr Babaki, Amir Chronic Diseases Research Center - Endocrinology and Metabolism Population Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Djalalinia, Shirin Noncommunicable Diseases Research Center - Endocrinology and Metabolism Population Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Motlagh, Mohammad Esmaeil Department of Pediatrics - Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , Tajadini, Mohammad Hasan Department of Biotechnology - School of Pharmacy - Isfahan University of Medical Sciences, Isfahan, Iran , Asayesh, Hamid Department of Medical Emergencies - Qom University of Medical Sciences, Qom, Iran , Safari, Omid Department of Pediatrics - School of Medicine - Alborz University of Medical Sciences, Karaj, Iran , Kelishadi, Roya Department of Pediatrics - Child Growth and Development Research Center - Research Institute for Primordial Prevention of Noncommunicable Disease - Isfahan University of Medical Sciences, Isfahan, Iran
Abstract :
Introduction. There is controversial evidence on association of
serum acid uric (SUA) with cardiometabolic risk factors and
metabolic syndrome in adults. This study aimed to investigate the
associations of SUA levels, components of metabolic syndrome, and
other cardiometabolic risk factors, in a nationally representative
sample of Iranian adolescents.
Materials and Methods. This study included 132 participants who
met the criteria of metabolic syndrome and 235 participants without
metabolic syndrome. The participants were grouped according to
the tertiles of SUA. Metabolic syndrome was defined according to
the Adult Treatment Panel III criteria modified for children and
adolescents. The relationship between SUA and cardiometabolic
risk factors and metabolic syndrome was assessed by multivariable
logistic regression analysis.
Results. The mean age of the participants was 15.21 ± 2.35 years,
with no significant difference between the boys and the girls. The
participants whose SUA was categorized in the 2nd tertile and
those falling into the 3rd tertile had significantly higher systolic
blood pressure (P < .001) as compared with the lower tertile(s). A
similar trend was documented for the overall high blood pressure.
Metabolic syndrome was associated with the 2nd and 3rd tertiles
of SUA as compared to the lower tertile(s), in the adjusted model
(P < .001), with the risk increasing by at least 2 times.
Conclusions. Our study showed that those adolescents with
metabolic syndrome had higher SUA levels. Its association with
some components of metabolic syndrome supports that SUA might
be an additional component of metabolic syndrome even during
adolescence.
