Title of article
How the COVID-19 Overcomes the Battle? An Approach to Virus Structure
Author/Authors
Ahmadpour, Doryaneh Institute for Biomedicine - Sahlgrenska Academy - Centre for Ageing and Health-AgeCap - University of Gothenburg, Gothenburg, Sweden , Ahmadpoor, Pedram Department of Nephrology - Dialysis and Apheresis - Nimes University Hospital Center, Nîmes, France
Pages
6
From page
167
To page
172
Abstract
Coronaviruses primarily cause zoonotic infections, however in the
past few decades several interspecies transmissions have occurred,
the last one by SARS-CoV-2, causing COVID-19 pandemic, posing
serious threat to global health. The SARS-CoV-2 spike (S) protein
plays an important role in viral attachment, fusion and entry.
However, other structural and non-structural SARS-CoV-2 proteins
are potential influencers in virus pathogenicity. Among these
proteins; Orf3, Orf8, and Orf10 show the least homology to SARSCoV
proteins and therefore should be further studied for their
abilities to modulate antiviral and inflammatory responses. Here,
we discuss how SARS-COV-2 interacts with our immune system.
Farsi abstract
فاقد چكيده فارسي
Keywords
coronavirus , SARS-CoV-2 , spike protein , ACE2 , Nsps , ORFs , immune response , drugs
Journal title
Iranian Journal of Kidney Diseases (IJKD)
Serial Year
2020
Record number
2518982
Link To Document