The Immunologic Basis of COVID-19: a Clinical Approach

The novel severe acute respiratory syndrome coronavirus (SARS-CoV2) has leaded to a global infection and a pandemic afterwards. This pandemic is one of the greatest global challenges for the health system. In this review, the immunologic basis of the human body response after infection with SARSCoV2 has been reviewed with discussions on both innate and adaptive immunity. Due to the relatively short time after appearance of the problem, the currently available evidence exclusively dealing with SARS-CoV2 and the disease, coronavirus diseases 2019 (COVID-19) are scant; especially in the field of cellular and molecular medicine; however, previous studies especially focusing on SARS-CoV and MERS are available. At the final part of the manuscript, involvement of the main human organs with COVID-19 is briefed.