Title of article :
Chemical Composition and Biological Activities of Endophytic Fungus Talaromyces Wortmannii LGT-4, Cultured in CYM Medium
Author/Authors :
Yang. Zhong-Duo Department of Pharmaceutical Engineering - School of Life Science and Engineering - Lanzhou University of Technology, Lanzhou, China , Zhang, Yu Department of Pharmaceutical Engineering - School of Life Science and Engineering - Lanzhou University of Technology, Lanzhou, China , Zhao, Wei-Hua Department of Pharmaceutical Engineering - School of Life Science and Engineering - Lanzhou University of Technology, Lanzhou, China , Shu, Zong-Mei Department of Pharmaceutical Engineering - School of Life Science and Engineering - Lanzhou University of Technology, Lanzhou, China
Abstract :
In the present study, nine compounds (1-9) were isolated from Talaromyces wortmannii LGT-4 (anendophytic fungus from Tripterygium wilfordi) which was cultured in CYM Medium. Their structures were determined as 4-hydroxyphthalide (1), Fumitremorgin C (2), Ergosterol (3), 3-(2-hydroxypropyl)-8-hydroxy-3,4- dihydroisocoumarin (4), Cis-cyclo(L-Ala-L-Pro) (5), 6-Amino-3-(4-hydroxybenzyl)- 1,4-diazonane-2,5-dione (6), Aspergillumarin B (7), Deacetylisowortmin B (8), and Entonaemin A (9) based on NMR spectral data, as well as comparing with previous literature data. This is the first report of the isolation of compounds 1-2 and 4-7 from Talaromyces genus. All compounds were tested for their monoamine oxidase and phosphoinositide 3-kinase (PI3Kα) inhibitory activities. Compound 1, 5 showed moderate anti-monoamine oxidase activity with IC50 value of 35 μg/mL, 28 μg/mL, respectively. Compound 9 showed PI3Kα inhibitory activity with IC50 value of 10.3 μg/mL
Keywords :
Endophytic fungus , Monoamine oxidase inhibitors , Chemical composition , Talaromyces wortmannii , Tripterygium wilfordi
Journal title :
Iranian Journal of Pharmaceutical Research(IJPR)
