Author/Authors :
Kalantari Khandani, Behjat Assistant Professor - Gastroenterology and Hepatology Research Center - Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences , Shafieipour, Sara Assistant Professor - Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran , Mobasserfar, Amir Assistant Professor - Department of Internal Medicine - Rafsanjan University of Medical Scienses , Zahedi, Mohammad Javad Professor - Physiology Research Center - Kerman University of Medical Sciences , Hashemi, Mohammad Department of Clinical Biochemistry - School of Medicine - Zahedan University of Medical Sciences , Hayatbakhsh Abbasi, Mohammad Mahdi Gastroenterology and Hepatology Research Center - Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences , Darvish Moghadam, Sodaif Gastroenterology and Hepatology Research Center - Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences
Abstract :
Single nucleotide polymorphisms (SNPs) have been introduced as a new
genomic source for cancer. Therefore, it was decided to conduct a study to evaluate the rs3746444 polymorphism of miR-499 in patients with colon cancer in comparison with healthy subjects.
This case-control study was conducted to investigate rs3746444 polymorphism of
miR-499 in blood samples of case and control groups. Patients with a confirmed diagnosis of
cancer based on pathologic report were enrolled in the study as the case group and compared
with healthy subjects. The level of significance was considered at p< 0.05.
The mean of DNA count in samples was 63.17± 23.51 that was significantly higher
in the case group. The rs3746444 polymorphism of miR-499 was significantly higher in
patients with cancer compared to the healthy subjects (P < 0.05).
In this study, rs3746444 polymorphism of miR-499 was significantly higher in
patients with colon cancer, which indicated that people with this polymorphism had a higher risk for malignancy.
Keywords :
Rs3746444 , Polymorphism , miR-499 , Colon Cancer
