Title of article :
Measurement of Hansen Solubility Parameters of Human Stratum Corneum
Author/Authors :
Ezati, Negin Department of Pharmaceutics and Pharmaceutical Nanotechnology - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Roberts, Michael Therapeutics Research Centre - School of Medicine - Translational Research Institute - University of Queensland, Brisbane, QLD, Australia , Zhang, Qian School of Pharmacy and Medical Sciences - University of South Australia, Adelaide, SA, Australia , Moghimi, Hamidreza Protein Technology Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Hansen Solubility Parameters (HSP) of human stratum corneum (SC), an indication of polarity of this membrane, are very important for design and optimization of dermatological formulations. But, there is no directly measured data available in the literature for such a crucial property, which is the subject of the present investigation. HSP of the SC was measured by solvent uptake here. 18 solvents/mixtures with different HSP values were selected and their uptake by the SC was measured at 32°C. Solvents were then divided into good and bad solvents according to their uptake into the SC. The HSP discrete parts of “atomic dispersion forces (δD)”, “intermolecular forces (δP)” and “hydrogen bonding (δH)” were then calculated using uptake data and HSPiP software. Results showed that δD, δP, δH values of the SC at 32°C are 16.5, 12, 7.7 respectively. The obtained HSP values, which were measured for the first time here, were then used to interpret enhancement effects of permeation enhancers and uptake of vehicles by the SC using Relative Energy Difference (RED), with good correlations. SC HSP values can be further used in transdermal drug delivery, cosmetic formulations, safety issues etc
Keywords :
Human skin , Stratum corneum , Drug Permeation , Polarity , Hansen Solubility Parameters , Partitioning
Journal title :
Iranian Journal of Pharmaceutical Research(IJPR)
