Author/Authors :
Tabatabaei, Azardokht Research center of Pediatric Infectious Disease - Rasool Akram Hospital - Iran University of Medical Sciences, Tehran, Iran , Babaee, Mohammad Department of Biochemistry - Iran University of Medical Sciences, Tehran , Iran , Moradi, Nariman Cellular and Molecular Research Center - Research Institute for Health Development - Kurdistan University of Medical Sciences, Sanandaj, Iran , Nabavi, Mohammad Asthma and Allergy Research Center - Rasool Akram Hospital - Iran University of Medical Sciences, Tehran, Iran , Arshi, Saba Asthma and Allergy Research Center - Rasool Akram Hospital - Iran University of Medical Sciences, Tehran, Iran , Fallah, Soudabeh Department of Biochemistry, Tehran, Iran
Abstract :
Background: Asthmais a disease with chronic airwayinflammation, wherebythe airway hyper-reactivity increases. Oxidative stress
balance plays a critical role in asthma.
Objectives: The present study aimed to evaluate serum glutathione peroxidase (GPX) enzyme activity and selenium levels in patients
with asthma.
Methods: This case-control study was conducted on 64 children aged 1 - 5 years, 32 subjects as controls, and 32 subjects with asthma
who were selected randomly. The serum GPX activity and selenium levels of the studied subjects were determined spectrophotometrically.
Results: The present study showed that serumGPXactivity and Selenium (Se) levels of patients with asthma were significantly lower
than those of controls (P < 0.001, P < 0.05, respectively).
Conclusions: Reduction of serum GPX activity and Se concentration in patients could have a potential role in the pathogenesis and
modulation of asthma. Micronutrient supplementation of Se may be beneficial in asthma.
Keywords :
Glutathione Peroxidase , Selenium , IgG , Oxidative Stress , Asthma
