Title of article :
Genital Involvement in Pre-Pubertal Pediatric Population: a Rare Aspect of Crohn’s Disease
Author/Authors :
Ann Warsi, Qurratul University of California and San Francisco - Department of Epidemiology and Biostatistics - 1825 4th street - Mission Bay, San Francisco, USA , Kunduru, Meghana State University of New York Medical University - Syracuse, USA , Karjoo, Manoochehr SUNY Upstate Medical University - 750 East Adams Street - Syracuse, USA , Beg, Mirza SUNY Upstate Medical University - 750 East Adams Street - Syracuse, USA
Abstract :
Crohn’s disease is an inflammatory bowel disease (IBD), characterized by chronic intestinal inflammation that causes the loss of immune tolerance leading to bizarre inflammatory signals and disruption of mucosal barriers. Environmental triggers and interaction of genetic determinants also play an indispensible role. In this case report, we present a pre-pubertal girl with intermittent and refractory genital swelling. We emphasize that Crohn’s disease must be considered in the differential diagnosis of recurrent, non-tender, erythematous and edematous lesions of the genital area. We conclude with future directions for diagnosing and managing vulvar Crohn’s disease in pediatric population.
Keywords :
Crohn’s disease (CD) , Inflammatory Bowel Disease (IBD) , Infliximab , Tumor necrosis factor alpha (TNF-α) , Vulvar swelling
Journal title :
International Journal of Pediatrics
