Author/Authors :
Pham Van, Tran Biochemistry Department - Military Hospital 103, Hanoi, Vietnam , TViet, hang Le Nephrology and Hemodialysis Department - Military Hospital 103, Hanoi, Vietnam , Hoang Thi, Minh Biochemistry Department - Military Hospital 103, Hanoi, Vietnam , Thi Phuong, Lan Dam Biochemistry Department - Military Hospital 103, Hanoi, Vietnam , Thi, Hang Ho Biochemistry Department - Military Hospital 103, Hanoi, Vietnam , Pham Thai, Binh National Hospital of Endocrinology, Hanoi, Vietnam , Thi Quynh, Giang Nguyen National Hospital of Endocrinology, Hanoi, Vietnam , Nong Van, Diep Biochemistry Department - Backan Hospital, Vietnam , Dai, Sang Vuong Biochemistry Department - Thanh Nhan Hospital, Hanoi, Vietnam , Minh, Hop Vu Biochemistry Department - Military Hospital 103, Hanoi, Vietnam
Abstract :
Objectives: We aimed to determine the parameters of acid-base balance in patients with chronic renal failure (CRF) and the relationship between the parameters evaluating acid-base balance and creatinine clearance.
Methods: The current cross-sectional study was conducted on 300 patients with CRF (180 males and 120 females). Clinical examination and blood tests by taking an arterial blood sample for blood gas measurement as well as venous blood for biochemical tests to select study participants were performed.
Results: Patients with CRF in the metabolic acidosis group accounted for 74%, other types of disorders were less common. The average pH, PCO2, HCO3, tCO2 and BE of the patient group were 7.35 ± 0.09, 34.28 ± 6.92 mmHg, 20.18 ± 6.06 mmol/L, 21.47 ± 6.48 mmHg and -4.72 ± 6.61 mmol/L respectively. These parameters are lower than normal values and decrease by progressing chronic kidney disease (CKD) stage. These parameters correlated moderately with creatinine clearance.
Conclusions: In patients with CRF, metabolic acidosis is predominant, and acid-base balance parameters are positively correlated with creatinine clearance.
