Cholecystectomy: Long term effect on serum lipid profile and Vitamin D

Background: The association between cholecystectomy and abnormal lipids and later increase in the risk of diseases related to dyslipidemia showed controversial results. This study aims to evaluate the association of lipid profile and Vitamin D level before and after cholecystectomy. Materials and Methods: Ninety-eight patients with symptomatic gallstones were studied prospectively. Plasma concentration of cholesterol, triglycerides, LDL, HDL and vitamin D was analyzed preoperatively and postoperatively after six months of cholecystectomy. None of the patients received any lipid-lowering drug or dietary restriction. Results: Sixty-seven (68.4%) female and 31 (31.6%) male patients were studied for six months. There was a significant increase in total serum cholesterol besides a significant decrease in vitamin D and HDL serum level after six months. Also, there was a non-significant increase in the serum level of LDL and triglyceride. In stone based sub analysis the same results achieved. Conclusion: There was a significant decrease in plasma concentration of vitamin D and HDL and the significant increase in cholesterol , triglyceride, and LDL in cholecystectomy patients postoperatively. These changes in plasma lipids and Vitamin D are likely to have a significant effect on the development of different disease related to dyslipidemia such as coronary artery disease and low bone density after cholecystectomy in the long term.