Author/Authors :
Ashrafi, Farzaneh Department of Hematology and Oncology - School of Medicine - Isfahan University of Medical Sciences, Isfahan, Iran , Naeimi Tabiei, Mohammad Department of Hematology and Oncology - School of Medicine - Golestan University of Medical Sciences, Gorgan, Iran , Mousavi, Sarah Department of Clinical Pharmacy and Pharmacy Practice - School of Pharmacy and Pharmaceutical Sciences - Isfahan University of Medical Sciences, Isfahan, Iran , Nematbakhsh, Mehdi Water and Electrolytes Research Center - Department of Physiology - Isfahan University of Medical Sciences, Isfahan, Iran , Sotoodehnasab, Parisa School of Pharmacy and Pharmaceutical Sciences - Isfahan University of Medical Sciences, Isfahan, Iran , Janbabaei, Ghasem Department of Hematology and Oncology - School of Medicine - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
Background: Cisplatin (CP) is a potent antineoplastic agent in the treatment of
wide a range of cancers, but it is accompanied with nephrotoxicity, a major limiting side effect. The aim of the present study was to evaluate the possible protective effect of vitamin E in the prevention of CP-induced nephrotoxicity.
Method: In this randomized clinical trial, a total of 51 patients treated with CP
chemotherapy were randomly assigned to receive vitamin E supplementation (400
Iu/ daily) (N=26) or placebo (N=25). Serum creatinine, glomerular filtration rate
(GFR), and neutrophil gelatinase-associated lipocalin were measured prior to each
chemotherapy cycle and one month after the cessation of the cycles.
Result: Compared to the baseline, a significant decrease was observed in the
blood levels of neutrophil gelatinase-associated lipocalin and serum creatinine in the
vitamin E group (P=0.001). GFR was not reduced in the vitamin E group (P=0.001),
and vitamin E was generally tolerated well.
Conclusion: Our findings indicated that vitamin E exert protective effects against
CP-induced nephrotoxicity, a finding which requires larger studies for confirmation
Keywords :
Cisplatin , Nephrotoxicity , Neutrophil gelatinase-associated lipocalin , Vitamin E
