Author/Authors :
Yazdanpanah, Mohammad Javad Cutaneous Leishmaniasis Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Sharifi Sistani, Noorieh Department of Pathology - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Hosseini, Elnaz Cutaneous Leishmaniasis Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Vosoughi, Elham Cutaneous Leishmaniasis Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Hosseini, Saeid Department of Otorhinolaryngology - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Khajedaluee, Mohammad Department of Biostatistics and Epidemiology - School of Health - Mashhad University of Medical Sciences, Mashhad, Iran , Amel Jamehdar, Saeid Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :
Background: The relationship between HPV infection and skin squamous cell
carcinoma (SCC) development in immunocompetent individuals is unclear. Therefore,
the purpose of this study was to assess the association between HPV infection and
skin SCC.
Methods: HPV DNA prevalence was evaluated in the paraffin embedded specimens
of 70 immunocompetent patients, of which 35 patients had skin SCC and 35 had
normal skin. PCR technique and GP6/5 primers were utilized for HPV DNA detection.
Result: Based on this study, 14.3% of the cases (5 of 35, 2 with low risk and 3
with high risk viruses) and 2.9% of the controls (1 of 35 with low risk virus) had
papilloma viruses. However, there was no significant statistical relationship between
the HPV DNA presence and the SCC development in skin.
Conclusion: The direct effect of HPV on skin cancerogenesis remains questionable.
