Author/Authors :
Madabhavi, Irappa Department of Medical and Pediatric Oncology and Hematology - Kerudi Cancer Hospital, Bagalkot, Karnataka, India , KS, Sandeep Department of Radiation Oncology - Kerudi Cancer Hospital, Bagalkot, Karnataka, India , Lethika, Rahul Dharmarajan Department of Radiation Oncology - Kerudi Cancer Hospital, Bagalkot, Karnataka, India , Tumbal, Satish Department of Radiology - Kerudi Cancer Hospital, Bagalkot, Karnataka, India , Miskin, Arun T Department of Pathology - SNMCMedical College, Bagalkot, Karnataka, India , Sarkar, Malay Department of Pulmonary Medicine - Indira Gandhi Medical College, Shimla, Himachal Pradesh, India , Modi, Mitul Department of Pathology - University of Pennsylvania, Philadelphia, PA, USA
Abstract :
Hepatocellular carcinoma (HCC) is the commontumor of the liver and the third most common
cause of cancer-related mortality worldwide. Patients with HCC may have metastasis to
different sites. Intrahepatic and extrahepatic metastases are found in (~50–75%). Lung and
regional lymph nodes are the most commonly involved sites. Metastasis to bone, skin, and
adrenal glands are rare. Orbit metastasis and intracranial invasion are extremely rare. We are
presenting a case of HCC that metastasized to the orbital cavity. The patient presented with
progressive proptosis of the eyeball with retrobulbar and intracranial invasion and involvement
of the sub-scalp region. Based on the imaging findings, it was initially misdiagnosed as
meningioma; however, histopathological examination of the biopsy specimen resulted in a
definitive diagnosis of HCC metastasis. The present case reveals that the alternative diagnosis
of metastasis must be considered when diagnosing retrobulbar lesions in patients with HCC.
Keywords :
Hepatocellular carcinoma , Intraconal metastasis , Sorafenib , Imaging
