Author/Authors :
Hafazeh, Leila Department of Physiology - Arak University of Medical Sciences, Arak, Iran , Changizi-Ashtiyani, Saeed Department of Physiology - Arak University of Medical Sciences, Arak, Iran , Najafi, Houshang Medical Biology Research Center - Kermanshah University of Medical Sciences, Kermanshah, Iran , Ghasemi, Faezeh Blood Transfusion Research Center - High Institute for Research and Education in Transfusion Medicine, Tehran, Iran , Rahjoo, Tina Department of Physiology - Arak University of Medical Sciences, Arak, Iran , Babaei, Saeid Department of Anatomy - Arak University of Medical Sciences, Arak, Iran , Ramezani, Majid Department of Internal Medicine - Bagiatallah University of Medical Sciences, Tehran, Iran
Abstract :
Introduction: Considering the limitations of conventional therapeutic methods in renal failure, researchers are paying attention to the application of adipose-derived mesenchymal stem cells (AD-MSCs) and their protective effects against acute renal failure. This study aims to assess the therapeutic effects of AD-MSCs in gentamicin-induced renal failure in rats. Methods: In this study, 40 male Wistar rats were studied in control, sham, gentamicin treated with and without receiving AD-MSCs. After 10 days, blood samples were collected and hemodynamic parameters, malondialdehyde and ferric reducing antioxidant power (FRAP) measured in the right and left kidneys underwent histologic examination. Results: Gentamicin administration significantly increased plasma creatinine, blood urea nitrogen, oxidative stress parameters and histologic damages; while significantly reduced FRAP in the gentamicin-receiving group in comparison with the sham group. AD-MSCs treatment significantly improved renal function parameters, oxidative stress and histologic damages in comparison with the gentamicin receiving group. Conclusion: Intravenous injection of AD-MSCs in gentamicin-induced renal failure improved renal function, oxidative stress parameters and histologic damages.
Keywords :
Acute renal failure , Gentamicin , Mesenchymal stem cells , Oxidative stress
