Author/Authors :
Motahari, Paria Department of Oral Medicine - School of Dentistry - Tabriz University of Medical Sciences, Iran
Abstract :
BACKGROUND and AIM: Recurrent aphthous stomatitis (RAS) as a common oral lesion may be created due to oxidative
stress. In this study, we intend to examine the salivary antioxidant-oxidant status in patients with RAS.
METHODS: In this review study, all English and Persian articles were searched by relevant keywords from the PubMed,
ScienceDirect, Cochrane, Scopus and SID databases from 1995 to 30 March 2020. Two independent reviewers
performed the study selection using the specified eligibility criteria. Finally, Newcastle-Ottawa Scale (NOS) method
was used for the quality evaluation of studies.
RESULTS: A systematic search on the references led to the identification of 87 articles, of which 68 were excluded and
finally, 19 articles were included in the study. The majority of the studies (86%) showed no significant decrease in the total
antioxidant capacity (TAC). In 71% of the studies, the malondialdehyde (MDA) levels exhibited an increasing trend and in
all studies, Glutathione peroxidase (GPx) had a decreasing trend; the results in relation to uric acid were contradictory.
CONCLUSION: Beyond the need for more extensive research in this area, it can be concluded that since RAS has
multifactorial etiology, changes in the body’s antioxidant-oxidant status are considered as an effective factor along with
other factors.
Keywords :
Saliva , Aphthous , Stomatitis , Antioxidants , Oxidative Stress