Author/Authors :
Zarei, Mohammad Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Bazvand, Fatemeh Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Ebrahimiadib, Nazanin Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Roohipoor, Ramak Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Karkhaneh, Reza Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Farahani Dastjani, Afsar Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Imani Fouladi, Marjan Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Riazi Esfahani, Mohammad Department of Ophthalmology - Gavin Herbert Eye Institute - University of California - Irvine - CA - USA , Khodabande, Alireza Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Davoudi, Samaneh Department of Ophthalmology - University of Florida - Gainesville - Florida - USA , Ghasemi, Hamed Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran , Modjtahedi, Bobeck S Eye Monitoring Center - Kaiser Permanente Southern California - CA - USA
Abstract :
Purpose: The present study aimed to evaluate the frequency and risk factors of retinopathy of prematurity (ROP) among Iranian infants.
Methods: A retrospective cohort study was conducted on infants who had undergone screening for ROP
at Farabi Eye Hospital, between March 2016 and March 2017. Data were analyzed based on the presence
of extreme prematurity (gestational age ≤ 28 weeks), extremely low-birth-weight (≤ 1000 g), and multiplegestation (MG) infants.
Results: The prevalence of ROP was 27.28% (𝑛 = 543) among all screened infants, 74.4% for extremely
preterm (EP) infants, 77.5% for extremely low birth weight (ELBW) babies, and 27.25% for infants from MG
pregnancies. On multivariate analysis, gestational age, birth weight, and history of transfusion (𝑃 < 0.0001,
𝑃 < 0.0001, and 𝑃 = 0.04, respectively) were found to be significantly associated with ROP. More advanced
stages of ROP (𝑃 < 0.0001) were observed in EP and ELBW infants. Birth weight (𝑃 = 0.088), history of
transfusion (𝑃 = 0.066), and intubation (𝑃 = 0.053) were not associated with increased risk of ROP in EP
infants, while gestational age (𝑃 = 0.037) and history of transfusion (𝑃 = 0.040) were significant risk factors
for ROP in ELBW infants. Gestational age (P < 0.001) and birth weight (𝑃 = 0.001) were significantly associated
with ROP in infants from MG pregnancies in multivariate analysis.
Conclusion: ROP remains a commonly encountered disease, especially in ELBW and EP infants. The history of transfusion may have a role in stratifying the risk for ROP and guiding future screening guidelines.
Keywords :
Epidemiology , Frequency , Infants , Pediatric , Retinopathy of Prematurity , Risk Factors
