Synthesis of isoquinoline derivatives using activated acetylenic compounds

Abstract: In this work, synthesis of isoquinolines derivatives in excellent yield using multicomponent reaction of phthalaldehyde, ammonium actate, propiolate and alkyl chloride in the presense of catalytic amount of Fe3O4-MNPs in water at room temperature were investigated. The reduction of ferric chloride solution with orange peel water extract caused to synthesis of magnetic iron oxide nanoparticles (Fe3O4-NPs) as a green method. These compounds have biological potential because of isoquinoline or quinoline core. For this reason, the antimicrobial activity of some synthesized compounds was studied employing the disk diffusion test on Gram-positive bacteria and Gram-negative bacteria. The results of disk diffusion test showed that compound prevented the bacterial growth.