Title of article :
Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro- 2-heteroaryl)-1,3,4-Thiadiazole Derivatives
Author/Authors :
Yazdanian, M. Department of Medicinal Chemistry - Faculty of Pharmacy - Kerman University of Medical Sciences, Iran , Zihayat, B. Student Research Committee - Kerman University of Medical Sciences, Iran , Moshafi, M.H. Department of Pharmaceutics - Pharmaceutics Research Centre - Kerman University of Medical Sciences, Iran , Khodadadi, A. Department of Medicinal Chemistry - Faculty of Pharmacy - Kerman University of Medical Sciences, Iran , Peimani, A. Department of Medicinal Chemistry - Faculty of Pharmacy - Kerman University of Medical Sciences, Iran , Shamsaddini, A. Department of Medicinal Chemistry - Faculty of Pharmacy - Kerman University of Medical Sciences, Iran , Nourhashemi, M. Drug Design and Development Research Center - The Institute of Pharmaceutical Sciences (TIPS) - Tehran University of Medical Sciences, Iran , Foroumadi, A. Drug Design and Development Research Center - The Institute of Pharmaceutical Sciences (TIPS) - Tehran University of Medical Sciences, Iran
Abstract :
A new series of 2-(5-nitro-2-heteroaryl)-1,3,4-thiadiazole derivatives, including nitro
furan, nitro thiophene and nitro imidazole, were synthesized and screened in vitro for
their inhibitory activity against eight bacterial strains. The results showed that most of
the synthesized compounds were active against Gram-positive bacteria, determined by
MIC method. Among them, compounds 6a, 6b and 6d exhibited strong anti-bacterial
effects against the Gram-positive bacteria. The oxidation of synthesized compounds to
sulfinyl and sulfonyl bearing analogues did not improve the activity.
Keywords :
1,3,4-Thiadiazole , Antibacterial activity , Synthesis
