Author/Authors :
Jamaati, Hamidreza Chronic Respiratory Diseases Research Center - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences, Tehran , Dastan, Farzaneh Department of Clinical Pharmacy - Faculty of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran , Mirshafiei Langari, Zahra Department of Pharmaceutical Care - NRITLD - Shahid Beheshti University of Medical Sciences, Tehran , Eskandari, Raha Department of Pharmaceutical Care - NRITLD - Shahid Beheshti University of Medical Sciences, Tehran , Marjani, Majid Clinical Tuberculosis and Epidemiology Research Center - NIRTLD - Shahid Beheshti University of Medical Sciences, Tehran , Farzanegan, Behrooz Tracheal Diseases Research Center - NIRTLD - Shahid Beheshti University of Medical Sciences, Tehran , Abedini, Atefeh Clinical Tuberculosis and Epidemiology Research Center - NIRTLD - Shahid Beheshti University of Medical Sciences, Tehran , Moniri, Afshin Clinical Tuberculosis and Epidemiology Research Center - NIRTLD - Shahid Beheshti University of Medical Sciences, Tehran , Hashemian, Mohammadreza Clinical Tuberculosis and Epidemiology Research Center - NIRTLD - Shahid Beheshti University of Medical Sciences, Tehran , Tabarsi, Payam Clinical Tuberculosis and Epidemiology Research Center - NIRTLD - Shahid Beheshti University of Medical Sciences, Tehran , Velayati, Ali Akbar Clinical Tuberculosis and Epidemiology Research Center - NIRTLD - Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
Background: Antimicrobial stewardship program is a comprehensive,
longitudinal program designed to improve and measure the appropriateness of
antimicrobial use while increasing patients' safety, decreasing cost of patients'
care, and combating emerging antimicrobial resistance. Antimicrobial
resistance, specially emerging multidrug-resistance and extremely drugresistance gram negative bacteria, is an important concern in the modern world.
This is particularly problematic since antimicrobials in production pipelines are
not meeting the demand for the emerging resistance micro-organisms; in
another word "we are running out of options". Indiscriminate use of
antimicrobial may increase the risk for resistance, and drug toxicity. The aim of
this study is to implement an evidence-based antimicrobial stewardship
program in a tertiary referral hospital. This study will assure consistency of the
stewardship program and measure outcomes to further assess the effectiveness
of this program. Materials and Methods: After establishment of antimicrobial stewardship
committee and endorsement of policies the program will be conducted in all
hospital medical wards. In an observational study, all patients receiving
antimicrobials included in the program will be closely monitored for primary
and secondary outcomes. Hospital's antimicrobial resistance patterns are
monitored periodically to assess improvement. The quality indicators will be
assessed to ensure proper execution of the program over time.
Results: As a study protocol, there are no results available to be reported at this
time.
Conclusion: We are expecting to observe significant reduction in cost of
antibiotic use shortly after program execution. By more appropriate utilization
of antibiotics patients' safety will be increased. Furthermore, we are expecting
to detect improvement in antimicrobial resistance patterns.
