Title of article :
Effect of Chamomile Hydroalcoholic Extract on BleomycinInduced Pulmonary Fibrosis in Rat
Author/Authors :
Hemmati, Ali Asghar Department of Pharmacology - School of Pharmacy and Medicinal Plants Research Center - Ahvaz Jundishapur University of Medical Sciences, Ahvaz , Jalali, Amir Department of Toxicology - School of Pharmacy and Toxicology Research Center - Ahvaz Jundishapur University of Medical Sciences, Ahvaz - Department of Pharmacology and Toxicology - School of Pharmacy - Guilan University of Medical Sciences, Rasht , Keshavarz, Parastoo Department of Pharmacology - School of Pharmacy and Medicinal Plants Research Center - Ahvaz Jundishapur University of Medical Sciences, Ahvaz
Abstract :
Background: The aim of the present study was to investigate the effect of the
Chamomile hydroalcoholic extract on bleomycin-induced pulmonary fibrosis in
rat.
Materials and Methods: Rats (N.Mari, 180-220 g) of either sex were given a
single intratracheal instillation of bleomycin (7.5 IU/Kg) or the vehicle (saline).
Treatment groups were given the same dose of bleomycin and then received
different doses of oral chamomile hydroalcoholic extract (400, 600, 800, 1000,
and 1500 mg/kg/day) for two weeks.
Results: Histological and pharmacological experiments of bleomycin-treated
animals showed that bleomycin could cause marked pulmonary fibrosis within
two weeks. In addition, administration of Chamomile hydroalcoholic extract
reduced such damages in lung tissue in a dose-dependent manner. Best results
were obtained with 1500 /kg/day of Chamomile hydroalcoholic extract.
Conclusion: From the results of current study, it can be concluded that
Chamomile hydroalcoholic extract may be able to diminish the toxic effects of
bleomycin on the lung tissues. Such effect of Chamomile can be attributed to
the ingredients of this plant with anti-inflammatory and anti-oxidant
properties.
Keywords :
Pulmonary fibrosis , Bleomycin , Chamomile hydroalcoholic extract
Journal title :
Tanaffos (Respiration)
