Author/Authors :
Rostamian, Abdolrahman Department of Rheumatology - Valiasr Hospital - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Ghazanfari, Tooba Immunoregulation Research Center - Shahed University, Tehran, Iran , Najafizadeh, Reza Department of Rheumatology - Valiasr Hospital - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Nezhadseifi, Elham Department of Rheumatology - Valiasr Hospital - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Movasseghi, Shafieh Department of Rheumatology - Valiasr Hospital - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Arabkheradmand, Jalil Defense Health Research Center, Tehran, Iran , Rajabnia Chenary, Maryam Defense Health Research Center, Tehran, Iran , Jafarpour, Samira Defense Health Research Center, Tehran, Iran , Edalatifard, Maryam Thoracic Research Center - Tehran University of Medical Sciences, Tehran, Iran , Hosseinieselki Sari, Sajjad Thoracic Research Center - Tehran University of Medical Sciences, Tehran, Iran , Salehi, Mohammad Reza Department of Infectious Diseases - School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Raeeskarami, Seyed Reza Department of Pediatrics, Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Mahmoodi Aliabadi, Maedeh Central laboratory - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Jamali, Davoud Department of Immunology - Shahed University, Tehran, Iran , Sattarian, Mohammad Reza Simorgh Clinical Laboratory, Tehran, Iran , Baharvand, Elahe Department of Internal Medicine - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Roomi, Azin Department of nursing - Islamic Azad University, Tehran, Iran , Naghizadeh, Mohammad Mehdi Department of nursing - Islamic Azad University, Tehran, Iran
Abstract :
Background: Researchers have already reported a high level of interleukin (IL)-6 in patients affected by Coronavirus Disease 2019 (COVID-19). In this study, we investigated the surge of IL-6 level and its association with the clinical and paraclinical markers in these patients.
Materials and Methods: The study sample comprised 205 confirmed hospitalized patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and 70 healthy volunteer individuals. Routine laboratory examinations, including hematology, biochemistry, and hormone analysis, as well as IL-6 level measurement, were conducted. The patients grouped into 5 based on their IL-6 levels. Then, they were compared with regard to their need for mechanical ventilator and clinical laboratory routine tests.
Results: IL-6 levels were significantly higher in hospitalized patients compared with healthy individuals (P<0.001). The IL-6 level was approximately 10-fold of the normal range in 22.9% of the patients. Also, more than 56.1% of them signify IL-6 over 3-fold of the normal range. IL-6
