Title of article :
MCM-41-SO3H as an efficient reusable nano-ordered heterogeneous catalyst for the synthesis of divers 1- & 5-substituted 1H-tetrazoles
Author/Authors :
Matloubi Moghaddam, Firouz Laboratory of Organic Synthesis and Natural Products - Department of Chemistry - Sharif University of Technology, Tehran, Iran , Eslami, Mohammad Laboratory of Organic Synthesis and Natural Products - Department of Chemistry - Sharif University of Technology, Tehran, Iran , Ghadirian, Niloofar Laboratory of Organic Synthesis and Natural Products - Department of Chemistry - Sharif University of Technology, Tehran, Iran
Abstract :
An improved and efficient method for the synthesis of 1- & 5-substituted 1H-tetrazole derivatives has been described in the presence of nano-ordered MCM-41-SO3H as an effective heterogeneous catalyst. This metal-free protocol, [2+3] cycloaddition of sodium azide to various nitriles or ethyl N-phenyl formimidate intermediate under mild reaction conditions, afford a wide range of 1H-tetrazoles in good to excellent yields. The catalyst was reused for five times without significant loss of catalytic activity.
Keywords :
Nano-ordered MCM-41-SO3H , 1-& 5-substituted tetrazoles , Click chemistry , [2+3] cycloaddition
Journal title :
Scientia Iranica(Transactions C: Chemistry, Chemical Engineering)
