Effect of Combined Exposure to Chronic High Fat Diet and Arsenic on Kidney Function in Male Mice

A number of risk factors could potentially affect the process of arsenic-induced kidney diseases. Arsenic is a common environmental and occupational contaminant dispersed world-wide, which can have an influence on developing chronic kidney disease (CKD) by several mechanisms. In recent years, alteration in the lifestyle as well as food habits among the people led to an increased use of food comprising a high-fat level. This important susceptible factor can have an effect on toxicity induced by arsenic. The present study was designed to evaluate the chronic exposure high fat diet (HFD) on arsenic-induced oxidative stress in kidney tissue of mice. Mice were randomly divided into 6 different groups (n=12). A low fat diet (LFD) control, LFD + arsenic 25 ppm, LFD + arsenic 50 ppm, HFD control, HFD + arsenic 25 ppm, HFD +arsenic 50 ppm. At the end of experiments, body weight and kidney weight to body weight ratio, biochemical parameters, oxidative stress markers, and kidney histological were evaluated. Our study showed that HFD increased arsenic-induced kidney damage through oxidative stress in mice. These investigations could be important for clinical research to protect against arsenic-induced kidney toxicity.