Title of article
Common Genetic Variant of INSIG2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India
Author/Authors
srivastava, n. Department of Physiology - King George’s Medical University - Lucknow - Uttar Pradesh, India , prakash, j. Department of Physiology - King George’s Medical University - Lucknow - Uttar Pradesh, India , srivastava, a. Department of Physiology - King George’s Medical University - Lucknow - Uttar Pradesh, India , mittal , b. Department of Genetics - Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow - U.P., India , awasthi, s. Department of Pediatrics - King George’s Medical University - Lucknow - Uttar Pradesh, India , srivastava, p. Darbhanga Medical College and Hospital Near Karpuri Chowk Benta Laheriasarai Darbhanga Bihar 846003, India
Pages
9
From page
261
To page
269
Abstract
Obesity is a very common disorder resulting from an imbalance between food intake and energy
expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to
examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated
phenotypes in North Indian subjects. Methods: The variants were investigated for association in 642 obese and
non-obese individuals. The genotyping of INSIG2 (rs7566605) single nucleotide polymorphism was analyzed by
the TaqMan allelic discrimination protocol. Results: A significant association was observed for INSIG2 (rs7566605)
single nucleotide polymorphism with obesity and obesity-related phenotypes. Furthermore, a significant
relationship was found between the rs7566605 and insulin, homeostasis model of assessment-insulin resistance,
the percentage of body fat, fat mass, leptin, and adiponectin. Conclusion: The present study observed significant
association between INSIG2 (rs7566605) single nucleotide polymorphism and obesity, as well as obesityassociated
phenotypes in North Indian population.
Keywords
Polymorphism , Insulin resistance , Insulin , Body mass index , INSIG2
Journal title
Iranian Biomedical Journal(IBJ)
Serial Year
2017
Record number
2525029
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