Other language title :
بررسي زيست سازگاري درون تني و برون تني Fe3O4@SiO و 2 Fe3O4@ZnO به عنوان ماده حساس به نور براي تحويل داروي سرطان پستان هدفمند
Title of article :
In vivo and In vitro Biocompatibility Study of Fe3O4@ZnO and Fe3O4@SiO2 as Photosensitizer for Targeted Breast Cancer Drug Delivery
Author/Authors :
Naderi, E Nanobiotechnology Research Center - Baqiyatallah University of Medical Sciences, Tehran, Iran , Naseri, M. Department of Physics - Malayer University, Malayer, Iran , Taimouri Rad, H. Biotechnology Research Center - Baqiyatallah University of Medical Sciences, Tehran, Iran , Zolfaghari Emameh, R. Department of Energy and Environmental Biotechnology - National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran , Farnoosh, Gh. Biotechnology Research Center - Baqiyatallah University of Medical Sciences, Tehran, Iran , Ali Taheri, R. Nanobiotechnology Research Center - Baqiyatallah University of Medical Sciences, Tehran, Iran
Abstract :
The present study aimed to prepare Fe3O4 nanocarriers (NCs) by a thermal treatment
method. After the Fe3O4 (Fe) NCs was prepared, zinc oxide and silica nanoparticles
were added to it as Photosensitizer. The structure, morphology, and magnetic properties
of Fe3O4@ZnO (Fe@Zn) and Fe3O4@SiO2 (Fe@Si) NCs were determined by XRD,
FT-IR, FESEM, and VSM. Then, the loading and drug release of Fe, Fe@Zn, and
Fe@Si NCs were investigated. The curcumin (CUR) release of Fe@Zn+CUR and
Fe@Si+CUR increased from 30% and 26% at pH 7.4 to 53% and 57% at pH 5.5,
respectively. The cytotoxicity of Fe@Zn and Fe@Si NCs were determined by MTT
assay, hemolysis test, acute toxicity, and lethal dose test. The results showed that
Fe@Zn and Fe@Si were appropriate for Photodynamic Therapy (PDT) and in the next
step, the effect of Fe@Zn, Fe@Si, Fe@Zn+CUR, and Fe@Si+CUR NCs on MCF-7
cells under visible light were studied. Finally, the ranking of the destruction of
cancerous cells of MCF-7 using NCs under visible light was:
Fe@Zn+CUR>Fe@Zn>Fe@Si+CUR>Fe@Si.
Keywords :
Photosensitizer , Drug Delivery , Curcumin , Cytotoxicity , Magnetic properties
Journal title :
Journal of Sciences Islamic Republic of Iran
