Author/Authors :
Norouzinia , Mohsen Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Zali , Mohammad Reza Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Amir Houshang Mohammad Alizadeh . Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Karimkhani , Sara Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Chaleshi , Vahid Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Balaii , Hedieh Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Tarban , Peyman Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Nourian , Mahyar Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Asadzadeh Aghdaei , Hamid Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Shahrokh , Shabnam Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Irani , Shiva Department of Biology - Science and Research Branch - Islamic Azad University - Tehran, Iran
Abstract :
Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn’s disease
(CD), are inflammatory disorders that affect the gastrointestinal tract. A combination of inflammatory cytokines
has an important role in IBD development. Genome-wide association studies have shown that polymorphisms in
the interleukin-23R gene (IL-23R) increase susceptibility to IBD. The aim of this study was to investigate the IL-
23R 3' UTR SNP to determine a potential association between genotype distribution and IBD.
Methods: The case group included 102 IBD patients and the control group included 107 healthy individuals.
IL-23R polymorphisms rs10889677 were genotyped using PCR-RFLP analysis. RFLP results were confirmed
by direct sequencing.
Results: The allele and genotype frequencies in patients and controls were evaluated and compared, and no
significant association between this functional rs10889677 polymorphism and risk of IBD was observed
(P=0.587; adjusted OR: 0.89; 95% CI: 0.597-1.339). We also found no significant association between CD
(14.71%) and UC (85.29%) patients in allele or genotype levels (P>0.05).
Conclusions: Our results suggest that the rs10889677 A>C polymorphism is not a potential prognostic marker
in Iranian patients with IBD
Keywords :
Ulcerative colitis , rs10889677 , Interleukin 23 receptor , Inflammatory bowel diseases , Crohn’s disease
