improvement of kidney apelin and apelin receptor in nitro-l-arginine-methyl ester induced rats

background: we have investigated the effect of 8 weeks aerobic training (at) and ferula gummosis supplement (fg) on apelin and apelin receptor (apj), nitric oxide (no) and angiotensin converting enzyme (ace) of hypertensive rats. materials and methods: in a experimental study, 50 adult male wistar rats were classified into five groups; 1- at, 2- fg, 3- combination of aerobic training + ferula gummosa supplement (tfg), 4- nitro-l-arginine-methyl ester (l-name), 5- shame (control) groups (sh). the rats in the 1 to 4 groups received l-name (10 mg/kg, 6 times a week for 8 weeks). also, the 1 and 3 groups experienced the training of 15 to 22 m/min for 25 to 64 minutes, 5 times a week for 8 weeks, whereas, the 2 and 3 groups received ferula gummosis supplement (90 mg/kg, 6 times a week for 8 weeks). however, rats in 5 groups received nacl solution. results: at protocols resulted in a significant increase in apelin and apj as compared to control and l-name groups. the tfg protocols resulted in a markedly increase in apelin, apj and significantly decrease of ace levels as compared to l-name group. chronically administration of l-name resulted increased, ace, and reduced the levels of apelin, apj and no, as compared to control group. conclusion: the results in this study show that physical regular activity with and without herbal treatment induce amplification in apelin/apj system and down-regulation blood pressure in l-name induced hypertension in the rat kidney tissue.