Urginea maritima (L.) Baker (Liliaceae) extract induces more cytotoxicity than standard chemotherapeutics in the A549 non-small cell lung cancer (NSCLC) cell line

Aim: Urginea maritima (Um) is a plant native to especially Turkey and the Mediterranean area. In this study, we investigated whether Um extract exerted cytotoxicity on cancer cells.Materials and methods: We made various extracts of Um. These extracts in varying concentrations were added to an A549 NSCLC cell culture, alone or with gemcitabine and/or cisplatin. Growth inhibition was tested by the MTT assayand an Annexin V-FITC apoptosis detection kit Results: The onion Um extract (1 μg/mL) was more cytotoxic than cisplatin (1μg/mL), gemcitabine (1 nm/mL), and leaf Um extract (1 μg/mL) with P 0.001, P = 0.097, and P 0.001, respectively. The efficacy of Um extract was furtherimproved by the addition of an antioxidant cocktail to an IC50 value of 0.02 μg/mL.Conclusion: Um extract has been shown for the first time to be a strong candidate for drug development in solid tumors.Our studies continue to further define the specific antitumor compound(s) in this extract.