Title of article
Evaluation of dose-related genotoxicity of desflurane by SCE human lymphocytes
Author/Authors
Aydinli, Bahar Yüksek İhtisas Education and Research Hospital - Department of Anesthesiology, TURKEY , ÖZGÖK, Ayşegül Yüksek İhtisas Education and Research Hospital - Department of Anesthesiology, TURKEY , DEMİR, Zeliha Aslı Yüksek İhtisas Education and Research Hospital - Department of Anesthesiology, TURKEY , YAĞAR, Seyhan Yüksek İhtisas Education and Research Hospital - Department of Anesthesiology, TURKEY , Ergün, Mehmet Ali Gazi Üniversitesi - Faculty of Medicine - Department of Medical Genetics, Turkey , KARAER, Derya Gazi Üniversitesi - Faculty of Medicine - Department of Medical Genetics, TURKEY , İlhan, Mustafa Necmi Gazi Üniversitesi - Faculty of Medicine - Department of Public Health, TURKEY
From page
1037
To page
1041
Abstract
Aim: To evaluate dose-related genotoxicity of desflurane. In the literature, there are studies with equivocal data regarding the potential genotoxicity of inhalational anesthetics. However, it is important to know about the genotoxic safety of an anesthetic agent.Materials and methods: Two groups were enrolled into the study. The first group was maintained with a desflurane minimum alveolar concentration (MAC) of 0.5 and the second was maintained with 1 MAC of desflurane. Blood samples were obtained and studied at the baseline and after 3 h of anesthesia via sister chromatid exchange (SCE) assay.Results: In both groups, SCEs per cell were noted to increase after 3 h of anesthesia, though the increase was only significant in the 1 MAC group.Conclusion: There are limited data on the genotoxicity of desflurane. It seems that 1 MAC of desflurane has a genotoxic effect, as shown by SCE assay.
Keywords
Anesthesiology , desflurane , SCE
Journal title
Turkish Journal of Medical Sciences (TJMS)
Journal title
Turkish Journal of Medical Sciences (TJMS)
Record number
2529676
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